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PMID: 16962140 DOI: 10.1016/j.jns.2006.06.007 Keywords Soman (GD) Drug Class: Organophosphate Chemical Warfare Agent classified as a Nerve Agent Mechanism of Action: Inhibits the destruction of acetylcholine by cholinesterase Aging occurs within a half-life of only 2 minutes with soman Rapid aging can make it almost impossible to give pralidoxime rapidly enough to be beneficial after the first noticeable detection of symptoms of poisoning are felt, at which point a significant degree of aging has already occurred
These specialized intercellular junctions impart extremely low paracellular permeability and exceptionally elevated transendothelial electrical resistance, which is estimated to be approximately 500-to 600-fold higher than that of the peripheral vasculature (15)
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PloS One (2017) 12:e0169788
GHKCu is a small peptide that naturally binds copper
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